β-Lactamase Resistant Cephalosporins with Particular Reference to Cefuroxime

The effect of silver nanoparticles on Gram-negative bacilli Resistant to Extended-Spectrum Β-Lactamase Enzymes

Abstract: Background and objectives: Antibiotic resistant to Antimicrobial agents is one of the most important concern in hospitals, which can lead to increased costs, treatment fails and mortality rates. The aim of this study was identification of Gram-negative bacilli resistant to extended-spectrum β-lactamase Enzymes (ESBLs) and determination of the effect of silver nanoparticles on the...

Cefuroxime, a beta-lactamase-resistant cephalosporin with a broad spectrum of gram-positive and -negative activity.

The in vitro activity of cefuroxime, a cephalosporin antibiotic, was investigated against 604 isolates and compared with the activity of other beta-lactam compounds. Cefuroxime had activity comparable to that of other cephalosporins, including cefamandole and cefoxitin, against streptococcal and staphylococcal species; most streptococci were inhibited by 0.1 mug or less per ml, and staphylococc...

Mutations in β-Lactamase AmpC Increase Resistance of Pseudomonas aeruginosa Isolates to Antipseudomonal Cephalosporins.

Mutation-dependent overproduction of intrinsic β-lactamase AmpC is considered the main cause of resistance of clinical strains of Pseudomonas aeruginosa to antipseudomonal penicillins and cephalosporins. Analysis of 31 AmpC-overproducing clinical isolates exhibiting a greater resistance to ceftazidime than to piperacillin-tazobactam revealed the presence of 17 mutations in the β-lactamase, comb...

Constrictive pericarditis with particular reference to etiology.

Phagocytosis, with particular reference to encapsulated bacteria.

The phagocytic cells of the mammalian host provide a remarkable defense against a wide variety of bacteria, fungi, and protozoa. Whether they play a protective role in infections caused by viruses and rickettsiae is at present a matter of conjecture. The discovery of "pinocytosis" (Gey, 1954), however, and recent observations relating to bacterial endotoxins (Berthrong and Cluff, 1953; Braude e...